I started on it just less than 2 weeks ago, and I'm surrounded by ill people at work and already have a bit of a cold (nothing severe). it is "milder" than a lot of the other dmards in terms of side effects and activity x It is listed as having a mild immunosuppressant effect in my book on RA, but one of the reasons for the blood tests is to check that your immune system is not being suppressed too much (eg checking your white blood cell levels), so you shouldn't be completely vulnerable. Even after several years of taking lots of drugs I've not found any difference in the number of colds etc I get, and loads of people on here are teachers etc who get a lot of exposure to colds and coughs without too much problem. Chloroquine metabolism Hydroxychloroquine azathioprine gout medications Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis, prevent joint damage and reduce the risk of long- term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Plaquenil and Immune system disorder - a study from real-world data. Summary Immune system disorder is found among people who take Plaquenil, especially for people who are female, 50-59 old, have been taking the drug for 5 - 10 years, also take medication Enbrel, and have Pain. Hi everyone. Just wondered if anyone can tell me whether hydroxy suppresses the immune system. And if so, to what extent. I know it's not as harsh as some of the other drugs but just wondered what people's experiences are. Polly Thank you both, I thought it shouldn't be too bad and that it's pretty mild in comparison to other drugs. Always better to be well informed and I remember the consultant saying its bit a bad time of year to start on it as I've missed all the bugs round Christmas time so thought there may be a slim chance of it being suppressed. But do look after yourself, and make sure you eat well and don't get too tired as if you have a cold already you need to pamper yourself a bit more than you would have before RA. What does plaquenil do to the immune system Plaquenil Hydroxychloroquine - Side Effects, Dosage., Will you have Immune system disorder with Plaquenil - eHealthMe Plaquenil and pancreatitisPlaquenil macular hole Plaquenil is an antirheumatic drug that helps to modulate an overstimulated immune system and decrease pain and inflammation. It also shown effective in hitting cystic forms of Borrelia burgdorferi and alkalizing the intracellular compartment making antibiotics more effective. What does Plaquenil do? -. Hydroxychloroquine and the immune system Hi everyone. - NRAS. Medications that Weaken Your Immune System and Fungal.. After 1 1/2 yrs of my Rheumatologist after me to take the Plaquenil, I'm finally doing it. I have an eye doctors appointment this week and I'll take my first pill after the check up. I am so very scared of it. Thanks to luppylupus Thank you for explaining what the Plaquenil does and how it does it. My gyn oncologist was concerned that the Plaquenil may affect my immune system to ward of the hpv since we all know a good immune system is needed to fight the virus --- He understands the RA pain conundrum I have. Today, Plaquenil and other antimalarials are also used to treat and help prevent symptoms caused by certain autoimmune diseases such as rheumatoid arthritis RA, systemic lupus erythematosus, and discoid lupus, even though these diseases are not caused by malaria parasites.