Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Pharmacokinetics of chloroquine Will hydroxychloroquine help osteoarthritis Is nausea and flu like symptoms normal when taking plaquenil Dr. Noskow’s Case Report Plaquenil Toxicity Why it’s important to get your eyes routinely checked when on certain high- risk medications! What is plaquenil? Plaquenil is a medication commonly used in patients that have Rheumatoid Arthritis RA, Systemic Lupus Erythematosus SLE, Sjogrens Syndrome, and other inflammatory and autoiummune disorders. What are risk factors for developing Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported. This article focuses upon hydroxychloroquine retinopathy. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Plaquenil toxicity eye oct Recommendations on Screening for Chloroquine and., Hydroxychloroquine toxicity - EyeWiki Plaquenil dosage sjogren's syndrome The actual incidence of retinal toxicity from hydroxychloroquine is difficult to pin down because there is usually a long time between being started on the drug and the start of any identifiable retinal toxicity. The overall rate of probable retinal toxicity is in the range of 1 of every 200 people treated. What can Hydroxychloroquine Plaquenil do to my eyes?. The Risk of Retinal Toxicity with Plaquenil. Plaquenil Toxicity - Retina Image Bank. Ocular Surgery News The American Academy of Ophthalmology has published several dosing and screening recommendations for hydroxychloroquine to avoid potential retinal toxicity, yet some patients. Spectral domain optical coherence tomography as an effective screening test for hydroxychloroquine retinopathy the “flying saucer” sign. Fishman GA, Choi D, Shahidi M. Selective thinning of the perifoveal inner retina as an early sign of hydroxychloroquine retinal toxicity. Eye Lond 2010; 24 5756–762. quiz 763. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs.