Chloroquine in hepatic dysfunction

Discussion in 'North West Pharmacy Canada' started by libra, 25-Feb-2020.

  1. MAYDAN New Member

    Chloroquine in hepatic dysfunction


    Controlled studies in pregnant women show no evidence of fetal risk. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk. Animal studies show risk and human studies not available or neither animal nor human studies done. Contact the applicable plan provider for the most current information. D: Use in LIFE-THREATENING emergencies when no safer drug available.

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    Evidence Acquisition We searched MEDLINE Pub Med, OVID, MD Consult, SCOPUS and the Cochrane database for the following keywords liver disease, anesthesia and liver disease, regional anesthesia in liver disease, epidural anesthesia in liver disease and spinal anesthesia in liver disease, for the period of 1966 to 2013. Chloroquine is contraindicated in patients with psoriasis, retinal disease, or porphyria. The preparations of chloroquine available in the U. S. are bitter-tasting tablets; hydroxychloroquine is better tolerated in children. The introduction by Conan 1 of chloroquine as an antiamebic agent and his demonstration of its usefulness in hepatic amebiasis established the efficacy of a relatively nontoxic drug in amebic infections of the liver. These observations were soon confirmed by Shookhoff 2 in 12 cases, by Sodeman 3 in two, and by others. 4, 5, 6. The present report concerns our experiences with the two patients.

    Active against erythrocytic forms of Plasmodium vivax & P. malariae and most strains of Plasmodium falciparum Precise mechanism not known Bioavailability: ~89% Peak plasma time: 1-2 hr Distributed widely in body tissues (eg, eyes, heart, kidneys, liver, lungs) where retention prolonged; crosses placenta; enters breast milk Partially in liver Half-life: 3-5 days Excretion: urine (~70% as unchanged drug); acidification of urine increases elimination Small amounts may be present in urine months following discontinuation of therapy The above information is provided for general informational and educational purposes only.

    Chloroquine in hepatic dysfunction

    Hydroxychloroquine toxicity - EyeWiki, Chloroquine - an overview ScienceDirect Topics

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  6. In case of any defects in hearing, chloroquine should be immediately discontinued, and the patient closely observed see ADVERSE REACTIONS. Hepatic Effects. Since this drug is known to concentrate in the liver, it should be used with caution in patients with hepatic disease or alcoholism or in conjunction with known hepatotoxic drugs.

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    Hydroxychloroquine is a derivative of chloroquine that has both antimalarial and antiinflammatory activities and is now most often used as an antirheumatologic agent in systemic lupus erythematosis and rheumatoid arthritis. Hydroxychloroquine therapy has not been associated with liver function abnormalities and is an extremely rare cause of clinically apparent acute liver injury. Hepatic reactions to quinine are usually due to hypersensitivity reactions and chloroquine has occasionally been linked to allergic phenomenon, which may be accompanied by hepatic involvement. Chloroquine undergoes minor metabolism by the liver ~30% and most is excreted unchanged in the urine. Advanced cancer in the setting of liver dysfunction poses a dilemma for physicians, as many cancer chemotherapeutic agents undergo hepatic metabolism. Most cytotoxic drugs have a narrow therapeutic index, and the administration of chemotherapy to patients with liver impairment results in complicated safety issues. We present a concise review of cancer chemotherapy dosing in

     
  7. viper New Member

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    What next if plaquenil doesn't work? Mar 24, 2011 Had headaches with the plaquenil so went to the sulfar and predisone. Sulfar was a waste of time and since I had a little help from the plaquenil he switched me back to that with pain meds for the headaches and body. Recently i went back for app. and plaquenil had stopped doing anything so he added the methotrexate to it. I did not want to take it.

    Hydroxychloroquine Reviews Everyday Health