I am asking this question, because I started this med approx. 1 month ago and prior to taking it I rarely ever got sick with colds,flu etc. Baseline labs required before starting plaquenil Hydroxychloroquine type 2 diabetes fda Plaquenil and rheumatoid arthritis Plaquenil side effects skin rash For people with inflammatory arthritis, your immune system tends to focus on attacking your own body rather than outside threats like the coronavirus. And some of the medications used to manage these diseases also suppress the immune system, which can make patients more vulnerable to infection. Apr 01, 2013 Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree. Hydroxychloroquine is a disease-modifying anti-rheumatic drug DMARDregulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the Around 2 weeks ago, I came down with a doozy of an illness (flulike with croup like cough that just won't quit). The only thing that usually ever ailed me were the crappy Sjogrens symptoms. Does hydroxychloroquine suppress your immune system Hydroxychloroquine Plaquenil, Methotrexate Does it weaken my immune system? Chloroquine resistance mechanism of actionAralen phosphate side effectsSide effects of long term use of hydroxychloroquineChloroquine lichen planus This dosing would NOT apply to someone already taking plaquenil, because it has a very long ~ 30 days half-life, and it’s already in your system, so you just keep on keep’n on. This is not intended to be medical advice; this is just a reminder to refill whatever Rx for plaquenil you might already have. Having lupus, and being on plaquenil. Does that mean I have a.. Hydroxychloroquine Side-effects, uses, time to work. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Overall, most serious fungal infections are rare, but they do happen. They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. There is evidence that hydroxychloroquine may interfere with communication between cells in the immune system. This action suppresses the normally overactive immune response in lupus patients which may explain one reason Plaquenil works so well for those suffering with lupus. Drugs that can Harm the Immune System and Lungs. The flu is rarely deadly. It's flu that becomes pneumonia that kills. Prescription and over-the-counter drugs should be seriously considered on the list of things that could potentially make people more susceptible to having a flu that morphs into a deadly pneumonia.