Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

Discussion in 'Hydroxychloroquine 200mg' started by RazMan, 23-Feb-2020.

  1. Renoir XenForo Moderator

    Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    Intensified treatment and control efforts since the early 2000s have dramatically reduced the burden of Plasmodium falciparum malaria. However, drug resistance threatens to derail this progress. However, drug resistance threatens to derail this progress. Resistance to chloroquine, in the case of P. falciparum, is linked to mutations in the P. falciparum chloroquine resistance transporter pfcrt gene, which alters the transport and accumulation of the drug in the digestive vacuole DV of the parasite 7, 8. Oct 04, 2002 Plasmodium falciparum chloroquine resistance is a major cause of worldwide increases in malaria mortality and morbidity. Recent laboratory and clinical studies have associated chloroquine resistance with point mutations in the gene pfcrt. However, direct proof of a causal relationship has remained elusive and most models have posited a.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine: mechanism of drug action and resistance in plasmodium falciparum

    The mechanisms of resistance to antimalarial drugs in., Antiplasmodial activity of chloroquine analogs against.

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  3. Resistance to chloroquine has, however, steadily spread since the 1960s from two foci, one in South America and one in South East Asia. Throughout the 1980s, chloroquine resistance spread through Africa, the global heartland of malaria mortality and morbidity, and there are very few effective and affordable drugs to take its place.

    • Malaria Dissecting chloroquine resistance Current Biology.
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    Jan 22, 2018 Petersen, I. et al. Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter. Mol. Microbiol. 97, 381–395 2015. Drug transport is believed to be of crucial importance for understanding the mechanisms of chloroquine resistance, as it is clear that less chloroquine accumulates in chloroquine-resistant parasites than in chloroquine-sensitive parasites. It was originally thought that this lack of accumulation was the result of an efflux mechanism, and a P-glycoprotein was implicated as the pump responsible for the efflux. Krogstad DJ, Gluzman IY, Kyle DE, Oduola AM, Martin SK, Milhous WK, Schlesinger PH. Efflux of chloroquine from Plasmodium falciparum mechanism of chloroquine resistance. Science. 1987 Nov 27; 238 48311283–1285. Krogstad DJ, Schlesinger PH. A perspective on antimalarial action effects of weak bases on Plasmodium falciparum. Biochem Pharmacol.

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    Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat.

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures.