Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Chloroquine diphosphate structure Plasmodium resistance to chloroquine Elimination by route of exposure Chloroquine is eliminated very slowly. About 55% is excreted in urine and 19% in feces within 77 days following therapy with 310 mg for 14 days. Kidney in urine about 70% is unchanged chloroquine and 23% is desethylchloroquine. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of chloroquine to prevent and treat malaria in children. However, children are more sensitive to the effects of this medicine than adults. Clin Pharmacol Ther. 1983 Sep;343383-5. On the question of dose-dependent chloroquine elimination of a single oral dose. Gustafsson LL, Rombo L, Alván G, Björkman A, Lind M, Walker O. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine elimination route CHLOROQUINE SelfDecode Genome Analysis, Chloroquine Oral Route Before Using - Mayo Clinic Can glucose and bind to chloroquineChloroquine is used to treat Chloroquine is extensively distributed with an enormous total apparent volume of distribution Vd more than 100 L/kg, and a terminal elimination half-life of 1 to 2 months. As a consequence, distribution rather than elimination processes determine the blood concentration profile of chloroquine in patients with acute malaria. Pharmacokinetics of Quinine, Chloroquine and Amodiaquine.. On the question of dose-dependent chloroquine elimination of.. Aralen Chloroquine Uses, Dosage, Side Effects.. Chloroquine analogues in drug discovery New directions of uses, mechanisms of actions and toxic manifestations from malaria to multifarious diseases. Chloroquine and hydroxychloroquine, two. Elimination Route. Chloroquine and its metabolites slowly excreted by the kidneys; unabsorbed drug is excreted in feces. a Up to 70% of a dose is excreted unchanged in urine and up to 25% of dose may be excreted in urine as desethylchloroquine. a Small amounts of chloroquine may be present in urine for weeks, months. Chloroquine is detectable in the urine for up to a year after drug administration. 94 Urinary excretion is the main route of elimination for both chloroquine and desethylchloroquine.