Chloroquine mechanism of action in sle

Discussion in 'Chloroquine 250' started by Dort, 20-Mar-2020.

  1. sunb0y Moderator

    Chloroquine mechanism of action in sle


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Antiprotozoal-Malaria /Mechanism of action/ may be based on ability of chloroquine to bind and alter the properties of DNA. Chloroquine also is taken up into the acidic food vacuoles of the parasite in the erythrocyte. Antimalarial mode of action and resistance. Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. The antimalarial mechanism of action from chloroquine has not been fully elucidated.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action in sle

    Plaquenil - FDA prescribing information, side effects and uses, Chloroquine C18H26ClN3 - PubChem

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  5. Various autoimmune disease such as colitis, RA, and SLE are known to be caused by different cell types and mechanisms 42. Nevertheless, from a T cell perspective, they are commonly induced by T H.

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    Oct 01, 2018 Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Mechanism of Action. Chloroquine exerts its antimalarial effects by preventing the polymerization of heme into hemozoin a food source for the malarial parasite. Chloroquine forms a drug-hemozoin complex, and this complex caps the polymerizing chain, thereby preventing additional polymerization. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

     
  6. Ramzesc Guest

    hello hope everyone is welljust a quick question, i have been on methotrexate for 2 months increasing from 7.5 to 15 and now to 25mg.weekly now been given plaquenil 400mg daily, has anyone else been on this mixture and has it worked or how long should i wait to see if it works.i'm not expecting it to work over night but soon hopefullyi am still in so much pain everyday and hoping for some relieve soon. Methotrexate and Coronavirus Apologies if this. - LUPUS UK How is plaquenil hydroxychloroquine used to treat lupus? Methotrexate and plaquenil - @Kristinsaba1988.
     
  7. vlaaxt Well-Known Member

    Scared to take plaquenil. How can I be absolutely sure my. Have you ever heard of damage that continues after stopping plaquenil? That's what freaks me out the most. I'm hoping that so long as I don't have to take a dose over 400 mg and so long as I get frequent checkups from a qualified ophthalmologist though, the risk of experiencing serious/non-reversible eye-damage is infinitesimally small.

    Plaquenil Related Eye Problems - Fraser Eye