Chloroquine autophagy mice

Discussion in 'Chloroquine 250' started by youlkin, 19-Mar-2020.

  1. cro Guest

    Chloroquine autophagy mice


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    The authors used tumor cells from a cancer patient that were grown in mice. "Chloroquine, which targets autophagy, has been tried in cancer trials. Ironically, it was used in tumors with very high. In all mice treated over the course of 4 separate experiments, complete clinical regression of tumor in response to therapy was observed in 81% of mice treated with TAM/CQ or TAM/HCQ compared with 8% of mice treated with TAM/PBS P 0.005. Autophagy is activated in tumor cells that survive p53-dependent apoptosis. Effects of bafilomycin and chloroquine on autophagy and cell survival. Primary rat cortical neurons at DIV7 were used for experiments. A-D Western blot analyses of LC3-I and LC3-II in lysates in neurons exposed to increasing concentrations of bafilomycin baf or chloroquine CQ for 24 h.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine autophagy mice

    Chloroquine enhanced the anticancer capacity of VNP20009., JCI - Autophagy inhibition enhances therapy-induced apoptosis.

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  3. Chloroquine cannot be recommended for clinical use given its potential side effects, but we selected it for this study in IDS-KO mice to evaluate the mechanism of autophagy through an examination of the morphological effects.

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    Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Furthermore, CQ induces an autophagy-independent severe disorganization of the Golgi and endo-lysosomal systems, which might contribute to the fusion impairment. Strikingly, HCQ-treated mice also show a Golgi disorganization in kidney and intestinal tissues. Treatment with chloroquine increased the levels and restored the activity of Muscleblind-like RNA-binding proteins, improving muscle function and strength in animal models of myotonic dystrophy type 1, a study has found. The study, "Increased Muscleblind levels by chloroquine treatment improve.

     
  4. lobro New Member

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  5. DenMoroz Guest

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  6. guestion2007 Moderator

    Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. According to the Mayo Clinic, it can take up to six months' constant use before an effect is seen in RA 1. Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term.

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