While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. Malarone chloroquine resistance ncbi Lysosomotropic agent chloroquine Methemoglobinemia has also been reported from chloroquine toxicity, and retinal toxicity is a side-effect of long-term use. Q5. Would you decontaminate this child? Answer and interpretation. No – not yet. Decontamination should only be performed when the benefits outweigh the risks. Chloroquine is quinolone derivative known to exert dose‐related retinal toxicity, albeit in a variable manner. It is thought that variability in the presentation of chloroquine retinopathy may be the result of perturbations in drug bioavailability subsequent to oral ingestion. Chloroquine and hydroxychloroquine retinopathy rare if recommended dose limits followed ; Once visual symptoms develop, they cannot be reversed, and may worsen even if medication stopped; Monitoring with visual fields, optical coherence tomography, and electroretinography allows earlier detection of toxicity and may prevent disabling vision loss Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Chloroquine toxicity of retina Spotlight Case Chloroquine - The American Society of., Retinal toxicity of chloroquine hydrochloride administered. Detoxing from plaquenilChloroquine injection brand nameWhat must be evaluated while on hydroxychloroquinePlaquenil and tongue swellEffects of plaquenil on pregnancy Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Protecting your eyesight when taking Plaquenil Lupus.. Chloroquine and Hydroxychloroquine - Kellogg Eye Center. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine toxicity Disease Entity. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity. Diagnosis. For retinopathy, patients should be asked about poor central vision. Management. At the first signs of retinal toxicity, hydroxychloroquine should be stopped. Ocular findings of HCQ retinal toxicity as detected by various screening modalities. A female patient was diagnosed with HCQ retinal toxicity at the age of 53 years, having taken HCQ for 12 years at 400 mg/day. She was not obese and had no additional risk factors for toxicity. Chloroquine and hydroxychloroquine belong to the quinolone family. Although their therapeutic and toxic doses differ, they are related drugs with similar clinical indications for use and similar.