Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Plaquenil drug action Hydroxychloroquine for lichen planus eye side effects Hydroxychloroquine ibuprofen interaction The current American Academy of Ophthalmology AAO guidelines, published in 2016, recommend a maximum daily hydroxychloroquine dose of ≤5.0 mg/kg of real weight. These guidelines were established to minimize the likelihood of permanent vision loss related to hydroxychloroquine retinopathy. Adults 800 mg 620 mg base followed by 400 mg 310 mg base at 6 hours, 24 hours and 48 hours after the initial dose total 2000 mg hydroxychloroquine sulfate or 1550 mg base. The most recent 2016 guidelines from the American Academy of Ophthalmology AAO recommend the dose of HCQ ≤5 mg/kg real body weight to minimize toxicity 1. According to these new guidelines, the risk of HCQ retinal toxicity is less than 1 % in the first year of therapy and less than 2 % up to 10 years of therapy. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Plaquenil dosage mg kg ACR Actual-weight hydroxychloroquine dosing works in SLE., Plaquenil Dosage Guide - Show me a picture of plaquenilHow long has plaquenil been on the marketToo much hydroxychloroquinePlaquenil manufacturer couponChloroquine resistant malaria drug of choice The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. Taking Plaquenil for Rheumatoid Arthritis. New Guidelines on Hydroxychloroquine Dosage - Where Are We.. Recommendations on Screening for Chloroquine and.. At first, 13 milligram mg per kilogram kg of body weight taken as a single dose. Then, 6.5 mg per kg of body weight taken 6 hours, 24 hours, and 48 hours after the first dose. However, dose is usually not more than 800 mg for the first dose and not more than 400 mg for the next doses. Mg 5 mg base/kg/dose Max 400 mg 310 mg base/dose PO weekly on the same day of each week, starting 1 to 2 weeks before entering the endemic area and continuing for 4 weeks after leaving the area. Guidelines suggest hydroxychloroquine as an alternative to chloroquine. The higher the long-term dosage, the more likely that serious Plaquenil side effects especially eye damage may occur. Plaquenil Dosing for Rheumatoid Arthritis The recommended starting Plaquenil dose for rheumatoid arthritis treatment is 400 to 600 mg daily.