Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Alternatives to plaquenil for sjogrens Aralen malaria medication Plaquenil retinal screening Doctors give trusted answers on uses, effects, side-effects, and cautions Dr. Machanic on does hydroxychloroquine suppress the immune system been shown to affect the immune system. It tends to weaken it. All of my symtoms pretty much cleared up. Now this year I have been having things pop up that are related to a low immune system. Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack. I only take 200 mg a day. Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Hydroxychloroquine and the immune system Hi everyone., Is Plaquenil a immunosuppressant drug ? Autoimmune. Benlysta prednisone ldn and plaquenil for lupusPlaquenil eye testHydroxychloroquine cause yellow sweat stainsChloroquine tablet for malaria My LLMD just precribed Plaquenil to me. so far so good tho I am concerned about the Vision issues with this medication but from everything I read its very rare to have Vision problems and nothing I read said that it was an Immune suppressant. Is Plaquenil an immumo-suppressant?. Hydroxychloroquine Plaquenil. Is Hydroxychloroquine Plaquenil an Immunosuppressant.. Yes Rituximab rituxin is a monoclonal antibody to cd20 an antigen located on lymphocytes. One consequence of using this drug is a drop in lymphocyte numbers bad cells and good cells. This decline lowers the effectiveness of the immune system for a period of time. The number of patients taking immunosuppressive drugs for the management of autoimmune inflammatory conditions is increasing. The general practitioner needs to be active in preventing, monitoring and managing the adverse effects of these drugs even long after the treatment has ceased. Immunosuppressant drugs are a class of drugs that suppress, or reduce, the strength of the body’s immune system. Some of these drugs are used to make the body less likely to reject a.