Chloroquine in cancer therapy a double edged sword of autophagy

Discussion in 'Canadian Pharmacy' started by poisk56, 07-Mar-2020.

  1. CrashBoom XenForo Moderator

    Chloroquine in cancer therapy a double edged sword of autophagy


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    According to current research, autophagy inhibition has been applied to a variety of cancer therapies, such as glioma, myeloma, breast cancer, rectal cancer, and prostate cancer. As a “double-edged sword” in cancer, the regulatory mechanism of autophagy in cancer is complicated, but the observations about specific molecular markers of. In particular, the autophagy inhibitors chloroquine and hydroxychloroquine, commonly used antimalarial drugs, are currently being investigated in phase I and phase II trials in patients with glioblastoma and myeloma. 6 In other studies, treatment of various cancer cells with small-molecule autophagy inhibitors, such as 3-methyladenine. Evidence in favor of autophagy functioning as a tumor suppressor comes mostly from discoveries that inactivation of certain autophagy regulators causes cancer in mice and that some human tumors display loss of these regulators. For example, allelic loss of Becn1 causes increased tumor development in mice 22, 23.

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    Chloroquine in cancer therapy a double edged sword of autophagy

    Autophagy in Health and Disease A Double-Edged Sword, Autophagy in Cancer Promotes Therapeutic Resistance.

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  7. Autophagy is a homeostatic cellular recycling system that is responsible for degrading damaged or unnecessary cellular organelles and proteins. Cancer cells are thought to use autophagy as a source of energy in the unfavorable metastatic environment, and a number of clinical trials are now revealing the promising role of chloroquine, an autophagy inhibitor, as a novel antitumor drug.

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    Negative effects of autophagy; Cancer. the lysosomotropic agent chloroquine induces a myopathy in cultured cells and rats similar to that of a human disorder termed distal myopathy with rimmed vacuoles, as well as inclusion body myositis. A Double-Edged Sword. By Takahiro Shintani, Daniel J. Klionsky. Science 990-995. Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. Apr 13, 2009 Therefore, it is difficult to predict if inhibition of autophagy may sensitise resistant tumour cells to cytotoxic therapy. Fact is that autophagy plays a dual role in cancer. Our actual examinations suggest a basal enhanced level of autophagy in highly resistant cancer cells, which might promote growth and therapy resistance.

     
  8. Rubedo New Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. TREATMENT OF SEVERE MALARIA - Guidelines for the Treatment of. Untitled Document web.stanford.edu Chloroquine Prevention of Coronavirus Disease COVID-19 in.
     
  9. Mmonger User

    Download PDF Many systemic medications may cause retinal toxicity. Chloroquine And Hydroxychloroquine Toxicity - StatPearls. What are the symptoms of Plaquenil toxicity? Plaquenil Oral Uses, Side Effects, Interactions, Pictures.
     
  10. DANK&TIM Guest

    Clinical Pharmacokinetics and Metabolism of Chloroquine. This paper presents the current state of knowledge on chloroquine disposition, with special emphasis on stereoselectivity and microsomal metabolism. In addition, the impact of the patient’s physiopathological status and ethnic origin on chloroquine pharmacokinetics is discussed. In humans, chloroquine concentrations decline multiexponentially. The drug is extensively distributed, with a.

    Desethyl Chloroquine-d4 SCBT - Santa Cruz Biotechnology
     
  11. Ssilka07 Well-Known Member

    What does Plaquenil do? - Plaquenil is an antirheumatic drug that helps to modulate an overstimulated immune system and decrease pain and inflammation. It also shown effective in hitting cystic forms of Borrelia burgdorferi and alkalizing the intracellular compartment making antibiotics more effective.

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