Chloroquine effect on lysosomes

Discussion in 'Canadian Pharmacy' started by Diatrium, 03-Mar-2020.

  1. Yana Well-Known Member

    Chloroquine effect on lysosomes


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a lysosomotropic agent that prevents endosomal acidification 1. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes. This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes. In these experiments, we tested the hypothesis that chloroquine, a lysosomotropic agent which modifies protein and lipid metabolism by hepatocyte lysosomes, would alter the biliary excretion of lipids and lysosomal enzymes. We treated male rats for 5 days with intraperitoneal chloroquine 50 mg/kg body wt, n = 9 or saline n = 8 and collected bile for 6 h via bile fistulas; rats were then. In this study, ARPE-19 cells were treated with chloroquine to inhibit lysosomal function. Chloroquine-treated ARPE-19 cells demonstrate a marked increase in vacuolation and dense intracellular debris. These are identified as chloroquine-dilated lysosomes and lipid bodies with LAMP-2 and LipidTOX co-localization, respectively.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine effect on lysosomes

    Aralen chloroquine Malaria Drug Side Effects & Dosage, Effect of Chloroquine on the Form and Function of.

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  7. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

    • Chloroquine Oral Route Side Effects - Mayo Clinic.
    • Chloroquine treatment of ARPE-19 cells leads to lysosome..
    • Disruptive Effect of Chloroquine on Lysosomes in Cultured Rat..

    The effect peaks after 1-2 hours of ingestion, and it has a terminal elimination half-life of 1-2 months since it is stored and trapped in lysosomes. Mechanism The exact mechanism of chloroquine is unknown but there are many postulated theories. An important component of red blood cells, heme, is broken down by parasites. VIROLOGY 28, 355-362 1966 Effect of Chloroquine on Lysosomes and on Growth of Mouse Hepatitis Virus MHV-3 LIVIO MALLUCCI1 National Institute for Medical Research, Mill Hill, London, England Accepted October 21, 1965 After a 6-hour treatment with chloroquine, infected mouse peritoneal macrophages produce markedly less mouse hepatitis virus than untreated cells. Chloroquine is a useful antimalarial and anti-inflammatory drug. It affects the lysosomes of malarial parasites 15, those of leukocytes and pancreatic exocrine cells 6, 7, and those of liver cells in the rat 4. In these examples the lysosomes are altered in structure, leading to the formation of myeloid bodies.

     
  8. leone Moderator

    Background: The American Academy of Ophthalmology recommendations on screening for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Hydroxychloroquine Ocular Toxicity Lessons Learned The. Plaquenil Toxicity - Bennett & Bloom Eye Centers Protecting your eyesight when taking Plaquenil Lupus Foundation of.
     
  9. xenix User

    Hydroxychloroquine Oral Route Side Effects - Mayo Clinic General feeling of tiredness or weakness headache inability to move the eyes increased blinking or spasms of the eyelid joint or muscle pain large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs loss of hearing lower back or side pain noisy breathing painful or difficult urination

    Hydroxychloroquine for Sjögren Syndrome Symptoms