It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. Hydroxychloroquine side efects Best generic plaquenil Plaquenil sleeplessness Hydroxychloroquin sulphate Names. Brand names include Chloroquine FNA, Resochin, and Dawaquin. History. Chloroquine was discovered in 1934 by Hans Andersag and coworkers at the Bayer laboratories, who named it "Resochin". 32 It was ignored for a decade because it was considered too toxic for human use. Unless otherwise noted, the contents of the FDA website gov, both text and graphics, are not copyrighted. They are in the public domain and may be republished, reprinted and otherwise used freely by anyone without the need to obtain permission from FDA. Structure, properties, spectra, suppliers and links for Chloroquine diphosphate, 50-63-5, Chloroquine Phosphate. People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes. Chloroquine iupac name Chloroquine Indications, Side Effects, Warnings -, S-Chloroquine C18H26ClN3 - PubChem Can plaquenil cause breast cancerHydroxychloroquine renal toxicity Brand names include Chloroquine FNA, Resochin, and Dawaquin. History. Its history goes back to Peru South America, where the indigenous people extracted the bark of the Cinchona trees and used the extract Chinchona officinalis to fight chills and fever in the seventeenth century. Chloroquine - Wikipedia. Chloroquine diphosphate C18H32ClN3O8P2 ChemSpider. Hydroxychloroquine C18H26ClN3O - PubChem. Name Chloroquine sulfate Drug Entry Chloroquine. Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. 4 It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. 17 Structure, properties, spectra, suppliers and links for Chloroquine Phosphate, 1446-17-9. Find patient medical information for Chloroquine Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.