Chloroquine and p62

Discussion in 'Canadian Pharmacy Online' started by MarikBY, 01-Mar-2020.

  1. z-shina Well-Known Member

    Chloroquine and p62


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Another widely used autophagy marker, p62, also called sequestosome 1 SQSTM1, binds directly to LC3 and GABARAP Atg8 orthologues family proteins via a short LC3 interaction region LIR. This may serve as a mechanism to deliver selective autophagic cargo for degradation by autophagy. The p62 protein recognizes toxic cellular waste, which is then scavenged by a sequestration process known as self-eating or autophagy. Lack of autophagy leads to accumulation of p62, which is not. Immunoprecipitation of SQSTM1/p62 protein from PANC-1 cell extracts. Lane 1 is 10% input, lane 2 is Mouse G3A1 mAb IgG1 Isotype Control #5415, and lane 3 is SQSTM1/p62 D5L7G Mouse mAb. Western blot was performed using SQSTM1/p62 D5L7G Mouse mAb. A light chain-specific secondary antibody was used to avoid reactivity with heavy chain IgG.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine and p62

    Frontiers Re-purposing Chloroquine for Glioblastoma., P62, an autophagy hero or culprit? Nature Cell Biology

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  3. Dec 13, 2016 The interactions of p62 and the UPS, autophagy and ubiquitinated proteins. Upon UPS inhibition, p62 is upregulated and phosphorylated on S405 and S409, which can facilitate the degradation of ubiquitinated cargoes via autophagy. p62 synthesis is induced by an increase in Nrf2 following UPS deficiency.

    • P62 links the autophagy pathway and the ubiqutin–proteasome..
    • CST - SQSTM1/p62 D5L7G Mouse mAb.
    • FAQs - Autophagy and LC3.

    Ab155686 staining SQSTM1/p62 autophagosome in control HeLa cells treated with ethanol 0.1% left panels and SQSTM1/p62 in HeLa cells treated with 1uM bafilomycin A1 for 18hrs right panels. The cells were fixed with methanol 5min, permeabilized with 0.1% Triton X-100 for 5 minutes and then blocked with 1% BSA/10% normal goat serum/0.3M. Check your blood sugar as you have been told by your doctor. A very bad and sometimes deadly reaction has happened with chloroquine. Most of the time, this reaction has signs like fever, rash, or swollen glands with problems in body organs like the liver, kidney, blood, heart, muscles and joints, or lungs. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

     
  4. Vyacheslav_St XenForo Moderator

    Interferes with digestive vacuole function within sensitive malarial parasites by increasing the p H and interfering with lysosomal degradation of hemoglobin; inhibits locomotion of neutrophils and chemotaxis of eosinophils; impairs complement-dependent antigen-antibody reactions Incomplete and variable (~70% [range: 25 to 100%]) (Tett 1993) Hepatic; metabolites include bidesethylchloroquine, desethylhydroxychloroquine, and desethylchloroquine (Mc Chesney 1966) Urine (15% to 25% [Tett 1993]; as metabolites and unchanged drug [up to 60%, Mc Chesney 1966]); may be enhanced by urinary acidification Rheumatic disease: May require several weeks to respond ~40 days (Tett 1993) ~40%, primarily albumin (Tett 1993) Lupus erythematosus: Treatment of chronic discoid erythematosus and systemic lupus erythematosus in adults. Plaquenil for Alopecia Areata, Alopecia Totalis - Full. Consider hydroxychloroquine in treating pediatric alopecia. Lichen planopilaris DermNet NZ
     
  5. h2o Well-Known Member

    In a systematic review and meta-analysis of 7 trials comprising 639 patients to evaluate the efficacy of mebendazole in children with giardiasis, investigators found no clinical difference in parasitologic cure between mebendazole and metronidazole, with a relative risk of 0.81 but high heterogeneity. Full text Treatment-refractory giardiasis challenges and solutions IDR Giardia Parasites CDC Giardiasis Giardia Infection Symptoms, Causes, Treatment
     
  6. SSAstudio Well-Known Member

    Chloroquine Phosphate – Marine Fish Diseases and Treatment The tablets are fine to use, but the downside is you get less “chloroquine base” out of them so you must dose more. The following was taken from Bob Goemans online book, THE LIVING AQUARIUM MANUAL In most cases, 250 mg tablets have an equivalence of 150 mg chloroquine base, and 500 mg tablets have an equivalence of 300 mg chloroquine base.

    Aralen chloroquine phosphate Price Comparisons - Discounts.
     
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