Synthesis of chloroquine

Discussion in 'Canadian Pharmacies-24h' started by speakeasy, 22-Feb-2020.

  1. Elizar New Member

    Synthesis of chloroquine


    Parasites that cause malaria typically enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia.

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    Chloroquine and its metabolites were prepared from 7‐chloro‐1,2,3,4‐tetrahydroquinolin‐4‐one through an aryl substitution with the corresponding amines; and the amodiaquine and its metabolites were prepared from 4,7‐dichloroquinoline in a similar fashion. A series of hybrid molecules referred to as “reversed chloroquines” RCQs were designed, synthesized, and tested against chloroquine resistant strains of Plasmodium falciparum. The designed compounds contain bulky aromatic groups and chloroquine like nucleus linked with each other via two or three carbon alkyl linkers. The following article looks at the medicinal chemistry of antimalarial drugs. It will look at – in detail – quinine and quinine-related drugs. In a previous article, we briefly described malaria and artemisinin as a lead compound for new antimalarials. We now turn our attention to the other antimalarial drugs.

    Chloroquine is also used to treat amebiasis (infection caused by amoebae). Chloroquine is used to treat and to prevent malaria.

    Synthesis of chloroquine

    High-yielding continuous-flow synthesis of antimalarial drug., Synthesis of New Chloroquine Derivatives as Antimalarial.

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  3. Mechanism of action Chloroquine basic concentrates in parasite food vacuole acidic. Prevent heme polymerization into hemozoin causing heme accumulation toxic to parasite. Drug complex with heme disrupt cell membrane function. Other mechanism include intercalating of parasite DNA, DNA synthesis inhibition. 7.

    • Chloroquine - SlideShare.
    • Medicinal Chemistry of Antimalarial Drugs.
    • Synthesis and antimalarial activity of new chloroquine..

    The first total synthesis of malagashanine, a chloroquine potentiating indole alkaloid, is presented. A highly stereoselective cascade annulation reaction was developed to generate the tetracyclic core of the Malagasy alkaloids. Chloroquine resistance Chloroquine is not effective against chloroquine- or hydroxychloroquine-resistant strains of Plasmodium species. Chloroquine resistance is widespread in P. falciparum and is reported in P. vivax. Prior to initiation of chloroquine for prophylaxis, it should be determined if chloroquine is appropriate for use in the. Chloroquine might be getting new life as an antiviral treatment for the novel coronavirus that emerged in Wuhan, China in late 2019 and has infected some 25,000 people in more than 25 countries. For decades, the drug was a front-line treatment and prophylactic for malaria.

     
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