If I take everything I have to take all at once I am so sick, worse than the normal sarc sick. I have no problems, but I also take a probiotic each day. I take most of my meds spaced out through the day (4x per day now down from 6x) and with food in order to minimize the side effects and get the junk in me. I'm hoping to stop this med over the summer it kills my stomach .. Hydroxychloroquine platelets Pfcrt chloroquine resistance The usual starting dose of Plaquenil is 200 mg twice a day or 400 mg once a day, administered orally, in people weighing 80 kg or more. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. You take plaquenil twice a day, approximately 12 hours apart. The most common side effect is mild nausea and occasional stomach cramps. You can take it with food if it upsets your stomach. You should also have a complete eye exam before starting this medication and then every 6 months. Plaquenil has been a life-saving drug for me, quite literally. I was a mess in 2004-2005 and then a dr put me on Plaquenil, and in 3 weeks most of my symptoms had disappeared. Within 2 months they were all completely gone, though my bloodwork continued to show very high levels of autoimmune stuff. Michele I have to take mine separate and each time with food. Otherwise they make me really sick and nauseous too. I'm supposed to only have a mild case of sarc ... Should you take plaquenil in the am or pm Plaquenil Oral Uses, Side Effects, Interactions., Best time to take plaquenil - HealthBoards Trametinib hydroxychloroquineDrug interaction of allopurinol and plaquenil Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Hydroxychloroquine Reviews Everyday Health. Plaquenil Uses, Dosage & Side Effects -. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. For radical cure of P. vivax and P. malariae infections, concomitant therapy with an 8-aminoquinoline compound is necessary. I take most of my meds spaced out through the day 4x per day now down from 6x and with food in order to minimize the side effects and get the junk in me. If I take everything I have to take all at once I am so sick, worse than the normal sarc sick. I am wondering if anyone has tried Plaquenil for PsA. If so, did it make your psoriasis worse? I've read of people who say that it did and others who say it did not. If it made your psoriasis worse, did your psoriasis get back to its pre-Plaquenil state after you stopped the Plaquenil? I'm considering Plaquenil for my next drug to try.