Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. How common is hair loss with plaquenil Plaquenil weight gain at 400mg Chloroquine and proguanil breastfeeding Chloroquine should be used with caution in patients with known porphyria cutanea tarda. Chloroquine can be used to treat porphyria cutanea tarda, but in a very low dose 125 mg twice weekly as a dosage of 250 mg/day can trigger a porphyria crisis, which can be fatal. Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria. It was the drug of choice to treat malaria until the development of newer antimalarials such as pyrimethamine, artemisinin, and mefloquine. Chloroquine was granted FDA Approval on 31 October 1949. Aralen chloroquine is an antimalarial drug used for the treatment of malaria and extraintestinal amebiasis. Common side effects are reduced hearing, tinnitus, nausea, vomiting, and diarrhea. Dosage, drug interactions, and pregnancy and breastfeeding safety are provided. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. What is chloroquine mode of action Mechanisms of drug action and resistance, Chloroquine - DrugBank Hydroxychloroquine and doxycyclineHow does plaquenil help rheumatoid arthritisDoes hydroxychloroquine cause swelling of legsPlaquenil dosing ideal body weightDoes hydroxychloroquine lower bad cholesterol Accordingly, WHO still recommends the treatment with chloroquine where this drug is effective, or an appropriate ACT in areas where P. vivax is resistant to chloroquine. 2.1. Antimalarial mode of action and resistance. Chloroquine acts exclusively in the erythrocyte stage of malaria parasites. Chloroquine Modes of action of an undervalued drug.. Aralen chloroquine Malaria Drug Side Effects & Dosage. Mode of Action of Chloroquine - Malaria Home Page. It is a prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses. PubChemThe mechanism of plasmodicidal action of chloroquine is not completely certain. Action of the drug chloroquine Chloroquine binds to heme or FP to form the FP-chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. Action of the toxic FP-chloroquine and FP results in cell lysis and ultimately parasite cell autodigestion. In essence, the parasite cell drowns in its own metabolic products.