Artemisinin and chloroquine structure

Discussion in 'Canada Pharmacy Online' started by Alex909, 12-Mar-2020.

  1. Rosie Moderator

    Artemisinin and chloroquine structure

    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Artemisinin or qinghaosu was isolated by Chinese researchers in 1972 from Artemisia annua, L. sweet or annual wormwood, and its structure was elucidated in 1979 Klayman, 1985. The plant has been used in traditional Chinese medicine as a remedy for chills and fevers for more than 2000 years. Efforts are ongoing to make other antimalarial compounds based on the structure of artemisinin and its mechanism of action. It is known that artemisinin requires hemoglobin digestion and the release of iron containing heme, which induces oxidative stress Klonis et al. 2011. Amodiaquine is a 4-aminoquinolone anti-malarial drug similar in structure and mechanism of action to chloroquine. Amodiaquine has tended to be administered in areas of chloroquine resistance while some patients prefer its tendency to cause less itching than chloroquine.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Artemisinin and chloroquine structure

    Qinghaosu artemisinin Chemistry and pharmacology, Artemisinin Discovery from the Chinese Herbal Garden

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  6. Artemisinin is an ancient Chinese herbal therapy for malarial fevers which has been recently found to have potent activity against many forms of malarial organisms, including chloroquine-resistant Plasmodium falciparum. Several artemisinin derivatives have been developed for clinical use in prevention and treatment of malaria, some of which have been linked to rare instances of acute liver injury.

    • Artemisinin C15H22O5 - PubChem.
    • Antimalarial medication - Wikipedia.
    • Qinghaosu Artemisinin The Price of Success Science.

    Artemisinin. Artemisinin was isolated by Chinese scientists in 1972 from Artemisia annua sweet wormwood, better known to Chinese herbalists for more than 2000 years as Qinghao. In the early 1970s, initial testing by Chinese scientists of Qinghao extracts in mice infected with malaria showed it to be as effective as chloroquine and quinine in. The following article looks at the medicinal chemistry of antimalarial drugs. It will look at – in detail – quinine and quinine-related drugs. In a previous article, we briefly described malaria and artemisinin as a lead compound for new antimalarials. We now turn our attention to the other antimalarial drugs. Chloroquine is a medication used to prevent and to treat malaria in areas where malaria is known to be sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

  7. Antonio Vivaldi Well-Known Member

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    Hydroxychloroquine Side Effects, Dosage, Uses, and More Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It’s also used to prevent and treat malaria. How it works. Hydroxychloroquine is an antimalarial drug.

    Hydroxychloroquine Side Effects Common, Severe, Long Term -
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