In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Chloroquine diphosphate salt solubility Hydroxychloroquine induced rash Hydroxychloroquine Retinal Toxicity. Proano C1, Kimball GP2. Author information 1Watts Eye Associates, Newburyport, MA [email protected] 2Haverhill, MA. PMID 31018072 Indexed for MEDLINE Publication Types Case Reports; MeSH terms. Antirheumatic Agents/adverse effects* Ocular side effects of hydroxychloroquine can include impact on the cornea, ciliary body, lens and retina. 1 Corneal deposits, fortunately, rarely affect vison. 2 However, the concern of retinal toxicity and the need for monitoring must be reviewed with patients prior to and during its use. 2,3 Several studies have reported risk factors for hydroxychloroquine HCQ retinal toxicity, but data are limited for patients of Asian ancestry. The aim of this study was to investigate the rate of and factors for HCQ retinal toxicity in the Korean population. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Retinal toxicity of hydroxychloroquine Hydroxychloroquine Plaquenil Toxicity and Recommendations., Ocular Disease Monitoring Critical to Avoid Retinal Toxicity from. What does plaquenil do for rheumatoid arthritisPlaquenil blurry visionAralen cloroquina para que sirveChloroquine mechanism of action immune system One of the most important appears to be dosage, with daily intake believed to be more significant than cumulative dosage. 6,18,19 Indeed, the majority of cases of retinal toxicity have been associated with a daily dosage of hydroxychloroquine of 6.5 mg/kg or more based on actual body weight. Retinal Toxicity Associated With Hydroxychloroquine and Chloroquine.. Risk of Retinal Toxicity in Longterm Users of Hydroxychloroquine The.. Determine risk for hydroxychloroquine retinal toxicity.. Baseline fundus photographs and FA are helpful in patients with pre-existing macular pigmentary changes. Patients are classified as being at a higher risk of developing toxicity if they exceed 3 mg/kg/day of chloroquine, or 6.5 mg/kg/day of hydroxychloroquine calculated based on ideal body weight. Retinal toxicity is unpredictable and can occur even at relatively low doses of hydroxychloroquine. There are new screening modalities for early detection of asymptomatic hydroxychloroquine ocular toxicity. PURPOSE To define the risk of hydroxychloroquine HCQ-related retinal toxicity in patients with rheumatoid arthritis RA and systemic lupus erythematosus SLE who are receiving recommended dosages of the drug or =6.5 mg/kg/day.