While many of these can be grouped by anatomic location or type of toxicity, there are also individual medications with characteristic effects. In this article, we will describe several major categories of pharmacologic retinal toxicity and discuss examples of individual medications. Oct findings with plaquenil toxicity Plaquenil sun sensitivity Mar 15, 2002 In the left eye, there was some mild mottling of the retinal pigment epithelium RPE in the macula. There was no subretinal fluid, but a foveal light reflex was present. Also, there were bone spicules in the inferior retina of the left eye. Our patients left eye shows bone spicules in the inferior retina. Oct 23, 2006 Retinal pigment epithelial RPE mottling in and around the macula of each eye was observed. A 1.5DD disc diameter area of RPE drop-out was noted slightly superior temporal from the macula O. D. Ocular coherence tomography OCT revealed what we interpreted as an old nonchoroidal non-neovascularized RPE detachment superior nasal from the right macula. Oct 07, 2008 Figure 6. A patient with Stargardt's disease and an identified mutation in the ABCA4 gene, presenting bilateral atrophy of the macula and retinal pigment epithelium that evidently reveals the choroidal vessels underneath. Subtle lipofuscin deposition surrounding the lesion was previously misdiagnosed as drusen. Both medications have been shown to bind melanin and to concentrate in the iris, ciliary body and retinal pigment epithelium, altering normal physiologic function. Chloroquine (Aralen) and hydroxychloroquine (Plaquenil) are traditional antimalarial agents now used in the treatment of autoimmune diseases, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Retinal pigment epithelial mottling of macula plaquenil Macular Disorders. Read about Macular Disorders. Patient, Does Patient with Lupus Have Plaquenil Retinopathy? Can i highlight my hair on plaquenil The pigmented layer of retina or retinal pigment epithelium is the pigmented cell layer just outside the neurosensory retina that nourishes retinal visual cells, and is firmly attached to the underlying choroid and overlying retinal visual cells. Retinal pigment epithelium - Wikipedia. How to Spot Diseases that Mimic Dry AMD. Hydroxychloroquine-Induced Retinal Toxicity - American.. Jun 11, 2009 Canthaxanthine is a vitamin A derivative used in the treatment of psoriasis and eczema, and had been used previously as an oral tanning agent. Toxicity has been shown after high-dose oral therapy of greater than 0.5 mg/kg/day. The retinal pigment epithelium RPE is a pigmented layer of the retina which can be thicker than normal at birth congenital or may thicken later in life. Areas of retinal pigment epithelial RPE hypertrophy usually do not cause symptoms. They are typically found during routine eye examinations. Congenital retinal pigment epithelial hypertrophy CHRPE is usually found before patients reach 30 years of age. Oct 01, 2019 Dystrophies primarily involving the retinal pigment epithelium. H35.54 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. The 2019 edition of ICD-10-CM H35.54 became effective on October 1, 2018.