Chloroquine vs quinine

Discussion in 'Aralen' started by origami, 29-Feb-2020.

  1. BI0SS Guest

    Chloroquine vs quinine


    Quinine is a basic amine and is usually provided as a salt. Various existing preparations include the hydrochloride, dihydrochloride, sulfate, bisulfate and gluconate.

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    USES Chloroquine Phosphate is a replacement for both copper sulfate and quinine and it is superior to copper sulfate and all quinine salts. Chloroquine is used as a bacteriacide, an algaecide and as an antimalarial. It is superior in the fight against ICH, slimness of the skin and flukes and can be used as both a treatment and a preventative. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. It continued to be used for its antimalarial properties until the 1920s, when other drugs with fewer side effects took its place, like chloroquine. That's almost 300 years of use. And somewhere along the way, quinine found its way into our cocktails.

    All quinine salts may be given orally or intravenously (IV); quinine gluconate may also be given intramuscularly (IM) or rectally (PR). In the United States, quinine sulfate is commercially available in 324-mg tablets under the brand name Qualaquin.

    Chloroquine vs quinine

    Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Chloroquine C18H26ClN3 - PubChem

  2. Retinal toxicity dosage hydroxychloroquine
  3. Quinine is an antimalarial drug which is made from Cinchona bark. The mode of action of quinine is similar to chloroquine. For the first time, the effects of quinine on the hexokinase activity of Plasmodium berghei P. berghei were reported by Fraser and Kermack in 1957.

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    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine 25 mg/kg over 3 d was compared to quinine 10 mg/kg 3 times daily for 5 d in 20 adult Filipino males with uncomplicated Plasmodium falciparum malaria in a double-blind, randomized trial. Quinine, chloroquine and mefloquine displaced 3 Hgranisetron with K i values of 15.0, 24.2 and 35.7 μ M. Docking of quinine into a homology model of the 5-HT 3 receptor binding site located the tertiary ammonium between W183 and Y234, and the quinoline ring towards the membrane, stabilised by a hydrogen bond with E129.

     
  4. Matold Well-Known Member

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  5. Andrew_chel XenForo Moderator

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  6. promobel Well-Known Member

    Protecting your eyesight when taking Plaquenil Lupus. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of.

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