I know I had never heard of it until my rheumatologist said that is what I have...along w/osteoarthritis and fibromyalgia. My blood tests are negative for RF but my CRP test was above normal. Ai Yi Yi Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells (these are messengers for your immune system, if you will) from interacting with your T-Cells (a special type of white blood cell which through a convoluted and boring process, causes inflammation when an infection is found, and these basically malfunction with inflammatory disorders). So, he started me on 400 mg of Plaquenil a day and he just upped it to 600 mg a day. As I said previously, my Rheumatologist now says it is inflammatory osteoarthrits. Why am I taking Plaquenil, which does help tremedously BTW, if I don't have RA or Lupus. This "dendritic deactivation" (I made that phrase up) helps reduce your immune system being silly and inflaming your joints. Plaquenil toxicity symptoms liver Chloroquine side effect homicide Difference between chloroquine and hydroxychloroquine The use of hydroxychloroquine HCQ in patients with systemic lupus erythematosus SLE is associated with reductions in serum low-density lipoprotein cholesterol LDL-C levels. Results of a literature search conducted by an international team of researchers was published in the International Journal of Rheumatic Diseases. Plaquenil, high cholesterol, trigeminal neuralgia, fibromyalgia, simvastatin I am on many medications but I have already had a bad side effect on 20 mg of Simvastatin and the doctor wants to try Atorvastatin but I was put on Plaquenil and I know I shouldn't take the two due to Peripheral Neuropathy problems that can occur and I have a history Auto Immune problems now but I also have Hyperlipidemia. Aug 14, 2017 Plaquenil is the brand name of hydroxychloroquine, a drug used to prevent or treat malaria 2. Plaquenil is also used for long-term treatment of autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythmatosis. My sister was dx'd with Inflammatory Arthritis and Plaquenil sent her into remission some years ago now. I also take meds for high bp, asthma and high cholesterol. Plaquenil and cholesterol A List of Medications That Increase Cholesterol Levels, Is there any cholesterol medication that can be taken. Chloroquine 250 mgPlaquenil and eye painPlaquenil liver kidney toxicityChloroquine phosphate reef safeChloroquine resistance in plasmodium vivax Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Long-Term Side Effects of Plaquenil for Rheumatoid Arthritis.. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Antimalarials such as hydroxychloroquine HCQ, are among the oldest prescribed drugs still used in clinical practice. Relatively inexpensive and well tolerated, these drugs have been recognized to be effective in autoimmune diseases such as rheumatoid arthritis RA and systemic lupus erythematosus SLE. Plaquenil may interact with acetaminophen, cancer medications, tuberculosis medications, birth control pills or hormone replacement therapy, arthritis medications, ACE inhibitors, antibiotics, antifungals, cholesterol medications, HIV/AIDS medications, NSAIDs non-steroidal anti-inflammatory drugs, or seizure medications. Tell your doctor all. Mar 07, 2008 My cholesterol was 218, which is the lowest it has been in 10 years, additionally my HDL and LDL were both in the normal range. I can not remember a time when my HDL and LDL were in the normal range, probably a good 30 years ago. The only new medication on my list is Plaquenil, does anyone know of a connection between Plaquenil and cholesterol.