It may have both an anti-spirochaete activity and an anti-inflammatory activity, similar to the treatment of rheumatoid arthritis. And caution is required if patients have certain heart conditions, diabetes, psoriasis etc. Hydroxychloroquine ear ringing Retinal damage plaquenil How does plaquenil treat rheumatoid arthritis The change in recommendations is based on the recent Food and Drug Administration FDA re-categorization of mefloquine from a pregnancy category C drug to category B, based on their review of the published data on mefloquine use during pregnancy. PLAQUENIL hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients Dibasic Calcium Phosphate, Hydroxypropyl Methylcellulose, Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. The most serious adverse effects affect the eye, with dose-related retinopathy as a concern even after hydroxychloroquine use is discontinued. The most common adverse effects are a mild nausea and occasional stomach cramps with mild diarrhea. Chloroquine pregnancy category Prophylactic use of antimalarials during pregnancy, PLAQUENIL® Best malaria medication for prevention of chloroquine-resistant malaria The authors found significant intrasubject variability in serum HCQ during pregnancy 11. Twenty-four percent of patients had at least 1 HCQ level 100 ng/ml, suggesting a high rate of nonadherence. Among the SLE pregnancies, those with nontherapeutic levels of HCQ 100 ng/ml. Too Little of a Good Thing Hydroxychloroquine in Pregnancy.. Hydroxychloroquine - Wikipedia. Plaquenil - Side Effects, Uses, Dosage, Overdose, Pregnancy.. Hydroxychloroquine Plaquenil and prednisone are considered safe during pregnancy. Methotrexate and cyclophosphamide Cytoxan should not be used in pregnancy and should be discontinued for at least a month prior to getting pregnant. Ask your doctor to help you weigh the benefits and risks all your medications. May 13, 2009 OR of congenital defects and live births. Other studies have reported that HCQ is safe to use during pregnancy but had no control group 35–40. All 4 of the studies 27–30 assessed the presence of congenital defects in babies born to women with autoimmune diseases Additional file 1, Table S2 and Figure 2a. Although it does not have an official FDA pregnancy classification, Aralen chloroquine phosphate is generally considered a pregnancy Category C medication. Some animal studies indicated that the drug might increase the risk of miscarriages, eye damage, and other problems.